Xenical has been experimented with several medicines and the results obtained are briefed below:
• On combining Xenical with Digoxin no specific change was observed. Normal healthy subjects taking 120mg Xenical thrice a day for six weeks were given a single dose of digoxin. Not a single change in the absorption, distribution, metabolism and elimination of digoxin became evident.
• 12 people with normal weight were offered 80 mg Xenical thrice a day for five days. When Glyburide was also administered into their bodies it was observed that the blood glucose lowering of glyburide remained the same.
• When 120 mg Xenical three times per day was given to 17 healthy people for 6 days the bioavailability of nifedipine remained unaffected.
• 12 people taking Warfarin administered Xenical three times per day for 16 days and neither pharmacodynamics nor pharmacokinetics of Warfarin seemed to be affected.
• 24 normal-weights, mildly hypercholesterolemic people were given both Pravastatin and Xenical at the same time. Xenical was offered to the patients for 6 days and it became noticed that Xenical didn`t effect the pharmacokinetics of Pravastatin.
• A group of 12 normal weight subjects taking Phenytoin were administered with Xenical dosage 120 mg three times a day for 7 days. The results obtained showed that Xenical has no effect either on the pharmacokinetics or on the pharmacodynamics of the patient.
• 120 mg Xenical thrice a day was given to 20 females of standard weight for 23 days. The resultant effect was that there was no change in the ovulation-suppressing action of oral contraceptives.
• In a special case study, 30 normal weight people were given 40 grams Xenical and alcohol. Neither in Xenical pharmacodynamics nor in alcohol pharmacokinetics was any change noticed.
• The experimental interaction of cyclosporine with Xenical led to a significant reduction in cyclosporine plasma level.
• A total of 30% reduction in beta-carotene absorption was observed when it was simultaneously administered with Xenical. |
